AAK1

AAK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WSQ, 5L4Q
Identifiers
Aliases	AAK1, AP2 associated kinase 1
External IDs	OMIM: 616405; MGI: 1098687; HomoloGene: 128746; GeneCards: AAK1; OMA:AAK1 - orthologs
EC number	2.7.11.1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	69,674,349 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	87,003,223 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; renal medulla; ; Pons; ; superior vestibular nucleus; ; ventral tegmental area; ; cardia; ; Brodmann area 23; ; pylorus; ; inferior ganglion of vagus nerve; ; parietal lobe;
	Top expressed in
	vestibular membrane of cochlear duct; ; substantia nigra; ; Paneth cell; ; transitional epithelium of urinary bladder; ; ciliary body; ; subiculum; ; retinal pigment epithelium; ; pontine nuclei; ; dentate gyrus of hippocampal formation granule cell; ; medial dorsal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; AP-2 adaptor complex binding; nucleotide binding; protein kinase activity; Notch binding; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity;
Cellular component	membrane; plasma membrane; terminal bouton; cell leading edge; clathrin-coated pit; extrinsic component of plasma membrane; clathrin-coated vesicle; cytoplasm; cytosol; nucleus;
Biological process	endocytosis; phosphorylation; protein stabilization; regulation of protein localization; protein autophosphorylation; positive regulation of Notch signaling pathway; protein phosphorylation; regulation of clathrin-dependent endocytosis; membrane organization; regulation of endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	22848
	269774
	ENSG00000115977
	ENSMUSG00000057230
	Q2M2I8
	Q3UHJ0
	NM_014911; NM_001371575; NM_001371577
	NM_001040106; NM_177762
	NP_055726; NP_001358504; NP_001358506
	NP_001035195; NP_808430; NP_001365581; NP_001365583; NP_001365584
	Wikidata
View/Edit Human	View/Edit Mouse

Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene and is involved in clathrin mediated endocytosis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.