AARS1

AARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XEO, 4XEM
Identifiers
Aliases	AARS1, CMT2N, EIEE29, alanyl-tRNA synthetase, AARS, alanyl-tRNA synthetase 1, DEE29, TTD8, HDLS2
External IDs	OMIM: 601065; MGI: 2384560; HomoloGene: 1213; GeneCards: AARS1; OMA:AARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	70,289,707 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	111,784,296 bp
RNA expression pattern
	Top expressed in
	beta cell; ; frontal pole; ; Brodmann area 10; ; right frontal lobe; ; middle frontal gyrus; ; paraflocculus of cerebellum; ; Brodmann area 9; ; stromal cell of endometrium; ; cingulate gyrus; ; cerebellar vermis;
	Top expressed in
	calvaria; ; left lobe of liver; ; facial motor nucleus; ; lacrimal gland; ; stroma of bone marrow; ; anterior horn of spinal cord; ; endothelial cell of lymphatic vessel; ; somite; ; primitive streak; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	n/a
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; amino acid binding; metal ion binding; ligase activity; RNA binding; nucleic acid binding; ATP binding; tRNA binding; alanine-tRNA ligase activity; aminoacyl-tRNA editing activity; Ser-tRNA(Ala) hydrolase activity; zinc ion binding; translation regulator activity;
Cellular component	membrane; mitochondrion; extracellular exosome; cytoplasm; cytosol;
Biological process	negative regulation of neuron apoptotic process; tRNA aminoacylation; protein biosynthesis; neuromuscular process controlling balance; tRNA processing; tRNA aminoacylation for protein translation; tRNA modification; neuromuscular process; cerebellar Purkinje cell layer development; regulation of translational fidelity; alanyl-tRNA aminoacylation; aminoacyl-tRNA metabolism involved in translational fidelity; regulation of cytoplasmic translational fidelity;
	Sources:Amigo / QuickGO
Orthologs
	16
	234734
	ENSG00000090861
	ENSMUSG00000031960
	P49588
	Q8BGQ7
	NM_001605
	NM_146217
	NP_001596
	NP_666329
	Wikidata
View/Edit Human	View/Edit Mouse

Alanyl—tRNA synthetase 1 (AARS1) is an enzyme that is encoded by the AARS1 gene in humans and is a member of the aminoacyl-tRNA synthetases (ARSs) family of enzymes.