AASDHPPT

AASDHPPT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BYD, 2C43, 2CG5
Identifiers
Aliases	AASDHPPT, AASD-PPT, LYS2, LYS5, CGI-80, ACPS, aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
External IDs	OMIM: 607756; MGI: 1914868; HomoloGene: 9130; GeneCards: AASDHPPT; OMA:AASDHPPT - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	106,098,699 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	4,309,471 bp
RNA expression pattern
	Top expressed in
	sperm; ; Epithelium of choroid plexus; ; frontal pole; ; postcentral gyrus; ; Brodmann area 23; ; superior frontal gyrus; ; superior vestibular nucleus; ; Pons; ; cerebellar vermis; ; orbitofrontal cortex;
	Top expressed in
	hand; ; endocardial cushion; ; atrioventricular valve; ; Paneth cell; ; spermatocyte; ; abdominal wall; ; left lobe of liver; ; urothelium; ; transitional epithelium of urinary bladder; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein binding; magnesium ion binding; metal ion binding; holo-[acyl-carrier-protein synthase activity];
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	lysine biosynthetic process via aminoadipic acid; pantothenate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	60496
	67618
	ENSG00000149313
	ENSMUSG00000025894
	Q9NRN7
	Q9CQF6
	NM_015423
	NM_026276; NM_001326359
	NP_056238
	NP_001313288; NP_080552
	Wikidata
View/Edit Human	View/Edit Mouse

L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase is an enzyme that in humans is encoded by the AASDHPPT gene.

The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia.