ABCA2

ABCA2
Identifiers
Aliases	ABCA2, ATP-binding cassette, sub-family A (ABC1), member 2, AI413825, Abc2, D2H0S1474E, mKIAA1062, ATP binding cassette subfamily A member 2, IDPOGSA
External IDs	OMIM: 600047; MGI: 99606; HomoloGene: 55590; GeneCards: ABCA2; OMA:ABCA2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,028,915 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,338,552 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right hemisphere of cerebellum; ; right frontal lobe; ; tibial nerve; ; middle frontal gyrus; ; Amygdala; ; inferior ganglion of vagus nerve; ; prefrontal cortex; ; Hypothalamus; ; sural nerve;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; choroid plexus of fourth ventricle; ; perirhinal cortex; ; central gray substance of midbrain; ; entorhinal cortex; ; CA3 field; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ATPase-coupled transmembrane transporter activity; nucleotide binding; transporter activity; ATPase activity; ATP binding; lipid transporter activity;
Cellular component	integral component of membrane; endosome; membrane; ATP-binding cassette (ABC) transporter complex; microtubule organizing center; lysosomal membrane; lysosome; endosome membrane; cytoplasmic vesicle; intracellular membrane-bounded organelle;
Biological process	regulation of intracellular cholesterol transport; lipid metabolism; regulation of transcription by RNA polymerase II; response to steroid hormone; cholesterol homeostasis; transmembrane transport; transport; lipid transport; response to cholesterol;
	Sources:Amigo / QuickGO
Orthologs
	20
	11305
	ENSG00000107331
	ENSMUSG00000026944
	Q9BZC7
	P41234
	NM_001606; NM_212533
	NM_007379; NM_001368624
	NP_001597; NP_997698
	NP_031405; NP_001355553
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family A member 2 is a protein that in humans is encoded by the ABCA2 gene.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene.