ABCA7

ABCA7
Identifiers
Aliases	ABCA7, ABCA-SSN, ABCX, AD9, ATP binding cassette subfamily A member 7
External IDs	OMIM: 605414; MGI: 1351646; HomoloGene: 22783; GeneCards: ABCA7; OMA:ABCA7 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,065,572 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,851,406 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; anterior pituitary; ; blood; ; spleen; ; right hemisphere of cerebellum; ; olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; minor salivary glands; ; monocyte; ; lymph node;
	Top expressed in
	granulocyte; ; lumbar spinal ganglion; ; tibiofemoral joint; ; interventricular septum; ; superior cervical ganglion; ; blood; ; fetal liver hematopoietic progenitor cell; ; islet of Langerhans; ; mesenteric lymph nodes; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; ATP binding; phosphatidylserine floppase activity; phosphatidylcholine floppase activity; apolipoprotein A-I receptor activity; transporter activity; ATPase-coupled transmembrane transporter activity; lipid transporter activity; protein binding;
Cellular component	integral component of membrane; endosome; Golgi apparatus; early endosome membrane; intracellular membrane-bounded organelle; membrane; ATP-binding cassette (ABC) transporter complex; Golgi membrane; plasma membrane; cell junction; phagocytic cup; cell surface; ruffle membrane; glial cell projection; cytoplasm; endoplasmic reticulum; cell projection;
Biological process	high-density lipoprotein particle assembly; cholesterol efflux; phagocytosis; phospholipid translocation; memory; positive regulation of cholesterol efflux; peptide cross-linking; phospholipid efflux; protein localization to nucleus; apolipoprotein A-I-mediated signaling pathway; negative regulation of amyloid precursor protein biosynthetic process; positive regulation of phagocytosis; positive regulation of ERK1 and ERK2 cascade; positive regulation of amyloid-beta clearance; positive regulation of engulfment of apoptotic cell; negative regulation of amyloid-beta formation; positive regulation of phospholipid efflux; transmembrane transport; lipid transport; amyloid-beta formation; negative regulation of endocytosis; amyloid-beta clearance by cellular catabolic process; regulation of amyloid precursor protein catabolic process; plasma membrane raft organization; positive regulation of protein localization to cell surface;
	Sources:Amigo / QuickGO
Orthologs
	10347
	27403
	ENSG00000064687
	ENSMUSG00000035722
	Q8IZY2
	Q91V24
	NM_019112; NM_033308
	NM_013850; NM_001347081
	NP_061985
	NP_001334010; NP_038878
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family A member 7 is a protein that in humans is encoded by the ABCA7 gene.