ABCB5

ABCB5
Identifiers
Aliases	ABCB5, ABCB5alpha, ABCB5beta, EST422562, ATP binding cassette subfamily B member 5
External IDs	OMIM: 611785; MGI: 1924956; HomoloGene: 83488; GeneCards: ABCB5; OMA:ABCB5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	20,777,038 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	118,930,156 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; corpus epididymis; ; gallbladder; ; gonad; ; skin of hip; ; tibia; ; caput epididymis; ; subcutaneous adipose tissue; ; gastric mucosa; ; retinal pigment epithelium;
	Top expressed in
	morula; ; zygote; ; secondary oocyte; ; primary oocyte; ; embryo; ; uterus; ; ovary; ; blastocyst; ; proximal tubule; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	efflux transmembrane transporter activity; nucleotide binding; ATPase activity; ATP binding; ABC-type xenobiotic transporter activity; ATPase-coupled transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	regulation of membrane potential; cell differentiation; compound eye corneal lens development; transmembrane transport; xenobiotic transport; xenobiotic transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	340273
	77706
	ENSG00000004846
	ENSMUSG00000072791
	Q2M3G0
	B5X0E4
	NM_001163941; NM_001163942; NM_001163993; NM_178559
	NM_029961
	NP_001157413; NP_001157414; NP_001157465; NP_848654
	NP_084237
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.