ABCC6

ABCC6
Identifiers
Aliases	ABCC6, ABC34, ARA, EST349056, GACI2, MLP1, MOAT-E, MOATE, MRP6, PXE, PXE1, URG7, ATP binding cassette subfamily C member 6
External IDs	OMIM: 603234; MGI: 1351634; HomoloGene: 55559; GeneCards: ABCC6; OMA:ABCC6 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	16,223,522 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,679,726 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; body of pancreas; ; human kidney; ; mucosa of transverse colon; ; renal cortex; ; upper lobe of left lung; ; body of stomach; ; right lung; ; right adrenal cortex;
	Top expressed in
	liver; ; left lobe of liver; ; yolk sac; ; lamina propria of urinary bladder; ; proximal tubule; ; right kidney; ; vein; ; detrusor urinae muscle; ; embryo; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase-coupled transmembrane transporter activity; nucleotide binding; ATPase activity; ATP binding; ATPase-coupled inorganic anion transmembrane transporter activity; transporter activity; transmembrane transporter activity;
Cellular component	endoplasmic reticulum; membrane; integral component of membrane; basolateral plasma membrane; endoplasmic reticulum membrane; nucleus; plasma membrane; apical plasma membrane; lateral plasma membrane; vacuolar membrane;
Biological process	response to stimulus; visual perception; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	368
	27421
	ENSG00000275331; ENSG00000091262
	ENSMUSG00000030834
	O95255
	Q9R1S7
	NM_001079528; NM_001171; NM_001351800
	NM_018795
	NP_001072996; NP_001162; NP_001338729
	NP_061265
	Wikidata
View/Edit Human	View/Edit Mouse

Multidrug resistance-associated protein 6 (MRP6) also known as ATP-binding cassette sub-family C member 6 (ABCC6) and multi-specific organic anion transporter E (MOAT-E) is a protein that in humans is encoded by the ABCC6 gene. The protein encoded by the ABCC6 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.

ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multidrug resistance.