ABCG4

ABCG4
Identifiers
Aliases	ABCG4, WHITE2, ATP binding cassette subfamily G member 4
External IDs	OMIM: 607784; MGI: 1890594; HomoloGene: 75179; GeneCards: ABCG4; OMA:ABCG4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,162,653 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,199,912 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; prefrontal cortex; ; lateral nuclear group of thalamus; ; oocyte; ; primary visual cortex; ; secondary oocyte; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; anterior cingulate cortex;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; cerebellar cortex; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior colliculus; ; dorsal tegmental nucleus; ; habenula; ; nucleus of stria terminalis; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; protein binding; ATP binding; cholesterol transfer activity; protein homodimerization activity; ABC-type sterol transporter activity; protein heterodimerization activity; ATPase-coupled transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	transmembrane transport; cholesterol efflux; cellular response to leukemia inhibitory factor; cholesterol transport;
	Sources:Amigo / QuickGO
Orthologs
	64137
	192663
	ENSG00000172350
	ENSMUSG00000032131
	Q9H172
	Q91WA9
	NM_001142505; NM_022169; NM_001348191; NM_001348192
	NM_138955
	NP_001135977; NP_071452; NP_001335120; NP_001335121
	NP_620405
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family G member 4 is a protein that in humans is encoded by the ABCG4 gene.

The protein encoded by this gene is included in the ATP-binding cassette transporter (ABC protein) superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.

ABCG4 has demonstrated, in vitro, to participate in the efflux of desmosterol and amyloid-β peptide (Aβ). It is highly expressed in the brain, but its localization and function at the blood-brain barrier (BBB) level remain unknown.