ABHD2

ABHD2
Identifiers
Aliases	ABHD2, HS1-2, LABH2, PHPS1-2, abhydrolase domain containing 2
External IDs	OMIM: 612196; MGI: 1914344; HomoloGene: 23121; GeneCards: ABHD2; OMA:ABHD2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	89,202,360 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,015,256 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; Achilles tendon; ; islet of Langerhans; ; gallbladder; ; spinal ganglia; ; sperm; ; duodenum; ; trigeminal ganglion; ; left testis; ; stromal cell of endometrium;
	Top expressed in
	retinal pigment epithelium; ; gastrula; ; seminal vesicula; ; ciliary body; ; pineal gland; ; decidua; ; adrenal gland; ; seminiferous tubule; ; submandibular gland; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carboxylic ester hydrolase activity; hydrolase activity; acylglycerol lipase activity; hormone binding; steroid hormone receptor activity; lipase activity; short-chain carboxylesterase activity;
Cellular component	integral component of membrane; membrane; sperm flagellum; cell projection; sperm plasma membrane; acrosomal vesicle; plasma membrane; cilium; motile cilium;
Biological process	negative regulation of cell migration; response to wounding; lipid metabolism; response to progesterone; lipid catabolic process; acylglycerol catabolic process; steroid hormone mediated signaling pathway; acrosome reaction; sperm capacitation; cellular lipid metabolic process; medium-chain fatty acid biosynthetic process; medium-chain fatty acid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11057
	54608
	ENSG00000140526
	ENSMUSG00000039202
	P08910
	Q9QXM0
	NM_007011; NM_152924
	NM_018811
	NP_008942; NP_690888; NP_008942.3; NP_690888.1
	NP_061281
	Wikidata
View/Edit Human	View/Edit Mouse

Abhydrolase domain-containing protein 2 is a serine hydrolase enzyme that is strongly expressed in human spermatozoa. It is a key controller of sperm hyperactivation, which is a necessary step in allowing sperm to fertilize an egg. It is encoded by the ABHD2 gene.