ACAD8

ACAD8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RX0
Identifiers
Aliases	ACAD8, ACAD-8, ARC42, acyl-CoA dehydrogenase family member 8, IBDH
External IDs	OMIM: 604773; MGI: 1914198; HomoloGene: 8662; GeneCards: ACAD8; OMA:ACAD8 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	134,265,855 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	26,910,862 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; cerebellar hemisphere; ; body of pancreas; ; right hemisphere of cerebellum; ; apex of heart; ; skin of leg; ; skin of abdomen; ; right frontal lobe; ; right lobe of liver;
	Top expressed in
	right kidney; ; Epithelium of choroid plexus; ; proximal tubule; ; neural layer of retina; ; muscle of thigh; ; granulocyte; ; left lobe of liver; ; human kidney; ; morula; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; oxidoreductase activity; acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	valine catabolic process; branched-chain amino acid catabolic process; regulation of transcription, DNA-templated; transcription, DNA-templated; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	27034
	66948
	ENSG00000151498
	ENSMUSG00000031969
	Q9UKU7
	Q9D7B6
	NM_014384
	NM_025862
	NP_055199
	NP_080138
	Wikidata
View/Edit Human	View/Edit Mouse

Isobutyryl-CoA dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ACAD8 gene on chromosome 11.

The protein encoded by ACAD8 is a mitochondrial protein belongs to the acyl-CoA dehydrogenase family of enzymes, which function to catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branched-chain amino acids. ACAD8 functions in catabolism of the branched-chain amino acid valine.