ACADS

ACADS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VIG
Identifiers
Aliases	ACADS, acyl-CoA dehydrogenase, C-2 to C-3 short chain, ACAD3, SCAD, acyl-CoA dehydrogenase short chain
External IDs	OMIM: 606885; MGI: 87868; HomoloGene: 20057; GeneCards: ACADS; OMA:ACADS - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	120,740,008 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,257,405 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; apex of heart; ; gastrocnemius muscle; ; muscle of thigh; ; left ventricle; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	white adipose tissue; ; renal cortex; ; proximal tubule; ; heart; ; human kidney; ; right kidney; ; colon; ; muscle tissue; ; quadriceps femoris muscle; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors; butyryl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; acyl-CoA dehydrogenase activity;
Cellular component	nucleus; mitochondrial matrix; mitochondrion; nucleoplasm;
Biological process	fatty acid beta-oxidation; lipid metabolism; metabolism; fatty acid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; butyrate catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	35
	11409
	ENSG00000122971
	ENSMUSG00000029545
	P16219
	Q07417
	NM_001302554; NM_000017
	NM_007383
	NP_000008; NP_001289483; NP_001289483.1
	NP_031409
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA dehydrogenase, C-2 to C-3 short chain is an enzyme that in humans is encoded by the ACADS gene. This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. The ACADS gene is associated with short-chain acyl-coenzyme A dehydrogenase deficiency.