ACER2

ACER2
Identifiers
Aliases	ACER2, ALKCDase, ASAH3L, alkalina ceramidasa, ALKCDase2, alkaline ceramidase 2
External IDs	OMIM: 613492; MGI: 1920932; HomoloGene: 14986; GeneCards: ACER2; OMA:ACER2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	19,452,505 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	86,853,059 bp
RNA expression pattern
	Top expressed in
	urinary bladder; ; gonad; ; placenta; ; subcutaneous adipose tissue; ; stomach; ; testicle; ; body of stomach; ; duodenum; ; body of pancreas; ; islet of Langerhans;
	Top expressed in
	transitional epithelium of urinary bladder; ; right lung; ; right lung lobe; ; left lung; ; embryo; ; tail of embryo; ; genital tubercle; ; gastrula; ; atrium; ; left lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	dihydroceramidase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; hydrolase activity; N-acylsphingosine amidohydrolase activity; ceramidase activity; metal ion binding;
Cellular component	integral component of membrane; integral component of Golgi membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	positive regulation of cell death; response to retinoic acid; ceramide metabolic process; lipid metabolism; sphingosine biosynthetic process; sphingolipid biosynthetic process; negative regulation of cell-matrix adhesion; positive regulation of cell population proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of cell adhesion mediated by integrin; cellular response to DNA damage stimulus; regulation of autophagy; DNA damage response, signal transduction by p53 class mediator; regulation of apoptotic process; ceramide catabolic process; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	340485
	230379
	ENSG00000177076
	ENSMUSG00000038007
	Q5QJU3
	Q8VD53
	NM_001010887
	NM_001290541; NM_001290543; NM_139306; NM_028605
	NP_001010887
	NP_001277470; NP_001277472; NP_647467
	Wikidata
View/Edit Human	View/Edit Mouse

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.