| Human ATP citrate lyase |
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Crystal structure of human ATP citrate lyase in complex with citrate, coenzyme A and Mg.ADP. |
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| Symbol | ACLY |
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| Alt. symbols | ACL |
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| NCBI gene | 47 |
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| HGNC | 115 |
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| OMIM | 108728 |
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| PDB | 3MWE, 3PFF, 5TDE, 5TDF, 5TDM, 5TDZ, 5TE1, 5TEQ, 5TES, 5TET, 6HXH, 6HXK, 6HXL, 6HXM, 6O0H, 6QFB 3MWD, 3MWE, 3PFF, 5TDE, 5TDF, 5TDM, 5TDZ, 5TE1, 5TEQ, 5TES, 5TET, 6HXH, 6HXK, 6HXL, 6HXM, 6O0H, 6QFB |
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| RefSeq | NM_001096 |
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| UniProt | P53396 |
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| EC number | 2.3.3.8 |
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| Locus | Chr. 17 q21.2 |
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ATP citrate synthase (also ATP citrate lyase (ACLY)) is an enzyme that in animals catalyzes an important step in fatty acid biosynthesis. By converting citrate to acetyl-CoA, the enzyme links carbohydrate metabolism, which yields citrate as an intermediate, with fatty acid biosynthesis, which consumes acetyl-CoA. In plants, ATP citrate lyase generates cytosolic acetyl-CoA precursors of thousands of specialized metabolites, including waxes, sterols, and polyketides.