ACOT7

ACOT7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QQ2
Identifiers
Aliases	ACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
External IDs	OMIM: 602587; MGI: 1917275; HomoloGene: 15780; GeneCards: ACOT7; OMA:ACOT7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,393,767 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,356,312 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; pars compacta; ; Pons; ; endothelial cell; ; anterior cingulate cortex; ; middle temporal gyrus; ; spinal ganglia;
	Top expressed in
	seminiferous tubule; ; anterior horn of spinal cord; ; medial dorsal nucleus; ; facial motor nucleus; ; dentate gyrus of hippocampal formation granule cell; ; central gray substance of midbrain; ; Medulla Oblongata; ; nucleus of stria terminalis; ; medial vestibular nucleus; ; perirhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	palmitoyl-CoA hydrolase activity; fatty-acyl-CoA binding; protein homodimerization activity; carboxylic ester hydrolase activity; long-chain fatty acyl-CoA binding; protein binding; hydrolase activity; acyl-CoA hydrolase activity; myristoyl-CoA hydrolase activity; thiolester hydrolase activity;
Cellular component	cytosol; nucleoplasm; mitochondrion; extracellular exosome; cytoplasm;
Biological process	medium-chain fatty acid biosynthetic process; medium-chain fatty-acyl-CoA catabolic process; long-chain fatty-acyl-CoA catabolic process; coenzyme A biosynthetic process; palmitic acid biosynthetic process; acyl-CoA metabolic process; lipid metabolism; fatty acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11332
	70025
	ENSG00000097021
	ENSMUSG00000028937
	O00154
	Q91V12
NM_181866; NM_007274; NM_181862; NM_181863; NM_181864;
	NM_181865
NM_001146057; NM_001146058; NM_133348; NM_001369273; NM_001369274;
	NM_001369275; NM_001369276
	NP_009205; NP_863654; NP_863655; NP_863656
NP_001139529; NP_001139530; NP_579926; NP_001356202; NP_001356203;
	NP_001356204; NP_001356205
	Wikidata
View/Edit Human	View/Edit Mouse

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.