ACOT8

ACOT8
Identifiers
Aliases	ACOT8, HNAACTE, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE, NAP1, acyl-CoA thioesterase 8
External IDs	OMIM: 608123; MGI: 2158201; HomoloGene: 3991; GeneCards: ACOT8; OMA:ACOT8 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,857,405 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,646,802 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right adrenal gland; ; right adrenal cortex; ; prefrontal cortex; ; left adrenal gland; ; left adrenal cortex; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; apex of heart;
	Top expressed in
	spermatid; ; duodenum; ; right kidney; ; spermatocyte; ; proximal tubule; ; granulocyte; ; jejunum; ; colon; ; left colon; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	palmitoyl-CoA hydrolase activity; choloyl-CoA hydrolase activity; long-chain acyl-CoA hydrolase activity; carboxylic ester hydrolase activity; medium-chain acyl-CoA hydrolase activity; protein binding; signaling receptor binding; hydrolase activity; CoA hydrolase activity; acyl-CoA hydrolase activity; acetyl-CoA hydrolase activity; succinyl-CoA hydrolase activity; acetoacetyl-CoA hydrolase activity; hydroxymethylglutaryl-CoA hydrolase activity; myristoyl-CoA hydrolase activity;
Cellular component	cytoplasm; peroxisome; peroxisomal matrix; cytosol;
Biological process	peroxisome organization; negative regulation of CD4 production; alpha-linolenic acid metabolic process; peroxisome fission; dicarboxylic acid catabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; viral process; bile acid biosynthetic process; fatty acid catabolic process; acyl-CoA metabolic process; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	10005
	170789
	ENSG00000101473
	ENSMUSG00000017307
	O14734
	P58137
	NM_005469; NM_183385; NM_183386
	NM_133240; NM_001362756; NM_001362757
	NP_005460
	NP_573503; NP_001349685; NP_001349686
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene.