ACP1

ACP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XWW, 3N8I, 4Z99, 4Z9A, 4Z9B, 5PNT
Identifiers
Aliases	ACP1, HAAP, LMW-PTP, acid phosphatase 1, soluble, LMWPTP, acid phosphatase 1
External IDs	OMIM: 171500; MGI: 87881; HomoloGene: 38274; GeneCards: ACP1; OMA:ACP1 - orthologs
EC number	3.1.3.2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	278,283 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	30,961,588 bp
RNA expression pattern
	Top expressed in
	sperm; ; Achilles tendon; ; left adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; ventricular zone; ; islet of Langerhans; ; body of pancreas; ; right testis; ; embryo;
	Top expressed in
	embryo; ; embryo; ; genital tubercle; ; right kidney; ; tail of embryo; ; blastocyst; ; ventricular zone; ; yolk sac; ; spermatid; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity; acid phosphatase activity;
Cellular component	cytoplasm; cytoplasmic side of plasma membrane; extracellular exosome; cytosol; sarcolemma;
Biological process	protein dephosphorylation; peptidyl-tyrosine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	52
	11431
	ENSG00000143727
	ENSMUSG00000044573
	P24666
	Q9D358
	NM_001040649; NM_004300; NM_007099; NM_177554
	NM_001110239; NM_021330
	NP_001035739; NP_004291; NP_009030
	NP_001103709; NP_067305
	Wikidata
View/Edit Human	View/Edit Mouse

Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene.

The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.