Prostatic acid phosphatase

ACP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CVI, 1ND5, 1ND6, 2HPA, 2L3H, 2L77, 2L79, 3PPD, 2MG0
Identifiers
Aliases	ACP3, 5'-NT, TM-PAP, ACP-3, acid phosphatase 3, acid phosphatase, prostate, ACPP
External IDs	OMIM: 171790; MGI: 1928480; HomoloGene: 55552; GeneCards: ACP3; OMA:ACP3 - orthologs
EC number	3.1.3.5
Gene location (Human)
Chr.	Chromosome 3 (human)
End	132,368,298 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	104,214,947 bp
RNA expression pattern
	Top expressed in
	prostate; ; sperm; ; human penis; ; urethra; ; monocyte; ; oral cavity; ; skin of thigh; ; germinal epithelium; ; vulva; ; gingival epithelium;
	Top expressed in
	lacrimal gland; ; molar; ; lumbar spinal ganglion; ; submandibular gland; ; skin of external ear; ; lip; ; Paneth cell; ; hair follicle; ; parotid gland; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	5'-nucleotidase activity; acid phosphatase activity; thiamine phosphate phosphatase activity; phosphatase activity; lysophosphatidic acid phosphatase activity; identical protein binding; hydrolase activity; protein binding; protein homodimerization activity;
Cellular component	integral component of membrane; membrane; vesicle membrane; filopodium; intracellular anatomical structure; extracellular region; lysosomal membrane; lysosome; extracellular exosome; nucleus; extracellular space; plasma membrane; azurophil granule membrane;
Biological process	regulation of sensory perception of pain; adenosine metabolic process; nucleotide metabolic process; positive regulation of adenosine receptor signaling pathway; purine nucleobase metabolic process; thiamine metabolic process; dephosphorylation; neutrophil degranulation; protein homotetramerization;
	Sources:Amigo / QuickGO
Orthologs
	55
	56318
	ENSG00000014257
	ENSMUSG00000032561
	P15309
	Q8CE08
	NM_001099; NM_001134194; NM_001292037
	NM_019807; NM_207668
	NP_001090; NP_001127666; NP_001278966
	NP_062781; NP_997551
	Wikidata
View/Edit Human	View/Edit Mouse

Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases.

The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels.

Certain medications can cause temporary increases or decreases in acid phosphatase levels. Manipulation of the prostate gland through massage, biopsy or rectal exam before a test may increase the level.

Its physiological function may be associated with the liquefaction process of semen.