SPG21

SPG21
Identifiers
Aliases	SPG21, ACP33, GL010, MAST, BM-019, spastic paraplegia 21 (autosomal recessive, Mast syndrome), maspardin, ABHD21, SPG21 abhydrolase domain containing, maspardin
External IDs	OMIM: 608181; MGI: 106403; HomoloGene: 9603; GeneCards: SPG21; OMA:SPG21 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,990,310 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,395,752 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; monocyte; ; right uterine tube; ; stromal cell of endometrium; ; secondary oocyte; ; canal of the cervix; ; islet of Langerhans; ; pericardium; ; gastric mucosa; ; palpebral conjunctiva;
	Top expressed in
	Ileal epithelium; ; retinal pigment epithelium; ; granulocyte; ; mandibular prominence; ; stroma of bone marrow; ; medial ganglionic eminence; ; white adipose tissue; ; hand; ; neural tube; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	CD4 receptor binding; protein binding;
Cellular component	Golgi apparatus; endosome membrane; trans-Golgi network transport vesicle; membrane; endosome; intracellular membrane-bounded organelle; cytosol; cytoplasm;
Biological process	antigen receptor-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	51324
	27965
	ENSG00000090487
	ENSMUSG00000032388
	Q9NZD8
	Q9CQC8
	NM_001127889; NM_001127890; NM_016630
	NM_138584; NM_001357813
	NP_001121361; NP_001121362; NP_057714
	NP_613050; NP_001344742
	Wikidata
View/Edit Human	View/Edit Mouse

Maspardin is a protein that in humans is encoded by the SPG21 gene.

The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4.