ACSL1

ACSL1
Identifiers
Aliases	ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2, acyl-CoA synthetase long-chain family member 1, acyl-CoA synthetase long chain family member 1
External IDs	OMIM: 152425; MGI: 102797; HomoloGene: 37561; GeneCards: ACSL1; OMA:ACSL1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	184,826,818 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	46,989,088 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; skin of thigh; ; blood; ; renal medulla; ; gastrocnemius muscle; ; adipose tissue; ; parotid gland; ; Skeletal muscle tissue of biceps brachii; ; skin of arm; ; pericardium;
	Top expressed in
	brown adipose tissue; ; tunica adventitia of aorta; ; subcutaneous adipose tissue; ; myocardium of ventricle; ; intercostal muscle; ; left lobe of liver; ; white adipose tissue; ; right ventricle; ; digastric muscle; ; sternocleidomastoid muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	long-chain fatty acid-CoA ligase activity; nucleotide binding; ligase activity; catalytic activity; ATP binding; decanoate-CoA ligase activity;
Cellular component	organelle membrane; integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; plasma membrane; peroxisomal membrane; peroxisome; mitochondrial outer membrane; mitochondrion; endoplasmic reticulum;
Biological process	linoleic acid metabolic process; lipid biosynthetic process; xenobiotic catabolic process; response to organic cyclic compound; response to nutrient; lipid metabolism; alpha-linolenic acid metabolic process; fatty acid transport; response to organic substance; adiponectin-activated signaling pathway; fatty acid metabolic process; positive regulation of protein serine/threonine kinase activity; long-chain fatty-acyl-CoA biosynthetic process; long-chain fatty acid import into cell; metabolism; long-chain fatty acid metabolic process; triglyceride metabolic process; response to oleic acid; regulation of lipid metabolic process; triglyceride biosynthetic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2180
	14081
	ENSG00000151726
	ENSMUSG00000018796
	P33121
	P41216
	NM_001286708; NM_001286710; NM_001286711; NM_001286712; NM_001995
	NM_007981; NM_001302163
NP_001273637; NP_001273639; NP_001273640; NP_001986; NP_001368806;
	NP_001368807; NP_001368808; NP_001368809; NP_001368810; NP_001368811; NP_001368812; NP_001368813; NP_001368814; NP_001368815; NP_001368816; NP_001368817; NP_001368818; NP_001368819
	NP_001289092; NP_032007
	Wikidata
View/Edit Human	View/Edit Mouse

Long-chain-fatty-acid—CoA ligase 1 is an enzyme that in humans is encoded by the ACSL1 gene.