ACSL4

ACSL4
Identifiers
Aliases	ACSL4, ACS4, FACL4, LACS4, MRX63, MRX68, acyl-CoA synthetase long-chain family member 4, acyl-CoA synthetase long chain family member 4, XLID63
External IDs	OMIM: 300157; MGI: 1354713; HomoloGene: 56282; GeneCards: ACSL4; OMA:ACSL4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	109,733,403 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	141,173,531 bp
RNA expression pattern
	Top expressed in
	monocyte; ; epithelium of colon; ; Achilles tendon; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; islet of Langerhans; ; gallbladder; ; left adrenal cortex; ; right lung;
	Top expressed in
	adrenal gland; ; gastrula; ; cumulus cell; ; left lung lobe; ; barrel cortex; ; medial dorsal nucleus; ; seminal vesicula; ; ventral tegmental area; ; decidua; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; arachidonate-CoA ligase activity; ligase activity; catalytic activity; very long-chain fatty acid-CoA ligase activity; ATP binding; decanoate-CoA ligase activity; long-chain fatty acid-CoA ligase activity;
Cellular component	cytoplasm; organelle membrane; integral component of membrane; mitochondria associated membranes; endoplasmic reticulum membrane; membrane; mitochondrial membranes; intracellular membrane-bounded organelle; lipid droplet; peroxisomal membrane; peroxisome; mitochondrial outer membrane; soma; endoplasmic reticulum; mitochondrion; extracellular exosome;
Biological process	response to interleukin-15; lipid biosynthetic process; response to nutrient; lipid metabolism; fatty acid transport; fatty acid metabolic process; embryonic process involved in female pregnancy; dendritic spine development; positive regulation of cell growth; long-chain fatty-acyl-CoA biosynthetic process; negative regulation of prostaglandin secretion; neuron differentiation; metabolism; triglyceride metabolic process; long-chain fatty acid metabolic process; triglyceride biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2182
	50790
	ENSG00000068366
	ENSMUSG00000031278
	O60488
	Q9QUJ7
	NM_004458; NM_022977; NM_001318509; NM_001318510
	NM_001033600; NM_019477; NM_207625
	NP_001305438; NP_001305439; NP_004449; NP_075266
	NP_001028772; NP_062350; NP_997508
	Wikidata
View/Edit Human	View/Edit Mouse

Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene.

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the intellectual disability or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.