ACSL5

ACSL5
Identifiers
Aliases	ACSL5, ACS2, ACS5, FACL5, acyl-CoA synthetase long-chain family member 5, acyl-CoA synthetase long chain family member 5
External IDs	OMIM: 605677; MGI: 1919129; HomoloGene: 69208; GeneCards: ACSL5; OMA:ACSL5 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	112,428,379 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	55,286,152 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of ileum; ; corpus epididymis; ; rectum; ; mucosa of transverse colon; ; mucosa of sigmoid colon; ; duodenum; ; right lobe of liver; ; endometrium; ; right uterine tube;
	Top expressed in
	jejunum; ; duodenum; ; ileum; ; skin of external ear; ; migratory enteric neural crest cell; ; transitional epithelium of urinary bladder; ; epithelium of stomach; ; left lobe of liver; ; right lung; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ligase activity; catalytic activity; ATP binding; long-chain fatty acid-CoA ligase activity; decanoate-CoA ligase activity;
Cellular component	integral component of membrane; mitochondrial outer membrane; nucleolus; mitochondrial inner membrane; nucleus; membrane; endoplasmic reticulum membrane; endoplasmic reticulum; mitochondrion;
Biological process	regulation of extrinsic apoptotic signaling pathway; lipid metabolism; fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; metabolism; long-chain fatty acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	51703
	433256
	ENSG00000197142
	ENSMUSG00000024981
	Q9ULC5
	Q8JZR0
	NM_203380; NM_016234; NM_203379; NM_001387037
	NM_027976
	NP_057318; NP_976313; NP_976314
	NP_082252
	Wikidata
View/Edit Human	View/Edit Mouse

Long-chain-fatty-acid—CoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene.

The protein encoded by this gene is an isozyme of the long-chain-fatty-acid-CoA ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.