Alpha-actinin-2

ACTN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H8B, 1HCI, 1QUU, 4D1E, 5A37, 5A36, 5A38, 5A4B
Identifiers
Aliases	ACTN2, CMD1AA, CMH23, actinin alpha 2, MYOCOZ, MPD6
External IDs	OMIM: 102573; MGI: 109192; HomoloGene: 31016; GeneCards: ACTN2; OMA:ACTN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	236,764,631 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	12,355,641 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; apex of heart; ; glutes; ; gastrocnemius muscle; ; right ventricle; ; triceps brachii muscle; ; myocardium of left ventricle; ; deltoid muscle;
	Top expressed in
	soleus muscle; ; ankle; ; myocardium of ventricle; ; extraocular muscle; ; digastric muscle; ; right ventricle; ; cardiac muscles; ; temporal muscle; ; tibialis anterior muscle; ; sternocleidomastoid muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein dimerization activity; protein homodimerization activity; transmembrane transporter binding; protein domain specific binding; titin Z domain binding; LIM domain binding; titin binding; metal ion binding; cytoskeletal protein binding; integrin binding; actin filament binding; protein binding; nuclear receptor coactivator activity; identical protein binding; FATZ binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; structural constituent of muscle;
Cellular component	cytoplasm; cytosol; pseudopodium; focal adhesion; filopodium; plasma membrane; sarcomere; dendritic spine; extracellular region; Z discdkac; cortical actin cytoskeleton; actin filament; extracellular exosome; cytoskeleton; platelet alpha granule lumen; postsynaptic density membrane; glutamatergic synapse; postsynaptic density, intracellular component;
Biological process	positive regulation of cation channel activity; regulation of apoptotic process; muscle contraction; positive regulation of potassium ion transport; phospholipase C-activating angiotensin-activated signaling pathway; cardiac muscle cell development; regulation of membrane potential; platelet degranulation; actin filament uncapping; MAPK cascade; focal adhesion assembly; negative regulation of protein localization to cell surface; positive regulation of signaling receptor activity; cell adhesion; negative regulation of potassium ion transmembrane transporter activity; negative regulation of potassium ion transport; regulation of nucleic acid-templated transcription; microspike assembly; positive regulation of endocytic recycling; muscle filament sliding; protein homotetramerization; sarcomere organization; positive regulation of potassium ion transmembrane transporter activity; protein localization to plasma membrane; positive regulation of nucleic acid-templated transcription; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	88
	11472
	ENSG00000077522
	ENSMUSG00000052374
	P35609
	Q9JI91
	NM_001103; NM_001278343; NM_001278344
	NM_033268
	NP_001094; NP_001265272; NP_001265273
	NP_150371
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal and cardiac muscles and functions to anchor myofibrillar actin thin filaments and titin to Z-discs.