ACVR2A

ACVR2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3Q4T, 3SOC, 4ASX
Identifiers
Aliases	ACVR2A, ACTRII, ACVR2, activin A receptor type 2A
External IDs	OMIM: 102581; MGI: 102806; HomoloGene: 20391; GeneCards: ACVR2A; OMA:ACVR2A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	147,930,826 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	48,793,281 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; hair follicle; ; oocyte; ; skin of thigh; ; testicle; ; skin of abdomen; ; lactiferous duct; ; ganglionic eminence; ; tendon; ; Achilles tendon;
	Top expressed in
	trigeminal ganglion; ; olfactory tubercle; ; subiculum; ; anterior amygdaloid area; ; medial ganglionic eminence; ; epithelium of lens; ; triceps brachii muscle; ; tail of embryo; ; genital tubercle; ; nucleus accumbens;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; PDZ domain binding; growth factor binding; coreceptor activity; activin binding; metal ion binding; kinase activity; protein self-association; protein serine/threonine kinase activity; transmembrane receptor protein serine/threonine kinase activity; inhibin binding; protein binding; activin-activated receptor activity; ATP binding; BMP receptor activity; transforming growth factor beta-activated receptor activity; transforming growth factor beta receptor activity, type II; type I transforming growth factor beta receptor binding; SMAD binding;
Cellular component	cytoplasm; integral component of membrane; inhibin-betaglycan-ActRII complex; membrane; receptor complex; plasma membrane; integral component of plasma membrane; cell surface; activin receptor complex;
Biological process	positive regulation of protein phosphorylation; male gonad development; ejaculation; positive regulation of erythrocyte differentiation; positive regulation of bone mineralization; phosphorylation; positive regulation of pathway-restricted SMAD protein phosphorylation; gastrulation with mouth forming second; penile erection; regulation of nitric-oxide synthase activity; cellular response to BMP stimulus; Sertoli cell proliferation; BMP signaling pathway; embryonic skeletal system development; regulation of BMP signaling pathway; protein phosphorylation; determination of left/right symmetry; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of activin receptor signaling pathway; positive regulation of osteoblast differentiation; regulation of signal transduction; spermatogenesis; mesoderm development; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; activin receptor signaling pathway; transforming growth factor beta receptor signaling pathway; pattern specification process;
	Sources:Amigo / QuickGO
Orthologs
	92
	11480
	ENSG00000121989
	ENSMUSG00000052155
	P27037
	P27038
	NM_001278579; NM_001278580; NM_001616
	NM_007396
	NP_001265508; NP_001265509; NP_001607
	NP_031422
	Wikidata
View/Edit Human	View/Edit Mouse

Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor.