ACVR2B

ACVR2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QLU, 4FAO, 2H62
Identifiers
Aliases	ACVR2B, ACTRIIB, ActR-IIB, HTX4, activin A receptor type 2B
External IDs	OMIM: 602730; MGI: 87912; HomoloGene: 863; GeneCards: ACVR2B; OMA:ACVR2B - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	38,493,142 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	119,264,061 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ganglionic eminence; ; endothelial cell; ; parotid gland; ; ventricular zone; ; Skeletal muscle tissue of biceps brachii; ; testicle; ; retinal pigment epithelium; ; lateral nuclear group of thalamus; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	Rostral migratory stream; ; somite; ; tail of embryo; ; renal corpuscle; ; epithelium of lens; ; epiblast; ; Ileal epithelium; ; mandibular prominence; ; embryo; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; growth factor binding; activin binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; transmembrane receptor protein serine/threonine kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; activin receptor activity, type II; ATP binding; transforming growth factor beta-activated receptor activity; transforming growth factor beta receptor activity, type II; type I transforming growth factor beta receptor binding; SMAD binding;
Cellular component	cytoplasm; integral component of membrane; membrane; receptor complex; plasma membrane; integral component of plasma membrane; protein-containing complex; activin receptor complex;
Biological process	pattern specification process; skeletal system development; roof of mouth development; regulation of transcription, DNA-templated; organ growth; embryonic foregut morphogenesis; kidney development; lymphangiogenesis; lung development; positive regulation of bone mineralization; retina vasculature development in camera-type eye; phosphorylation; lymphatic endothelial cell differentiation; skeletal system morphogenesis; gastrulation with mouth forming second; insulin secretion; negative regulation of transcription by RNA polymerase II; response to glucose; post-embryonic development; BMP signaling pathway; venous blood vessel development; odontogenesis of dentin-containing tooth; protein phosphorylation; heart development; blood vessel remodeling; determination of left/right symmetry; positive regulation of osteoblast differentiation; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of activin receptor signaling pathway; regulation of signal transduction; artery development; pancreas development; mesoderm development; activation of protein kinase activity; signal transduction; anterior/posterior pattern specification; activin receptor signaling pathway; transforming growth factor beta receptor signaling pathway; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	93
	11481
	ENSG00000114739
	ENSMUSG00000061393
	Q13705
	P27040
	NM_001106
	NM_007397; NM_001313757
	NP_001097
	NP_001300686; NP_031423
	Wikidata
View/Edit Human	View/Edit Mouse

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor.