ADAM17

ADAM17
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BKC, 1ZXC, 2A8H, 2DDF, 2FV5, 2FV9, 2I47, 2M2F, 2OI0, 3B92, 3CKI, 3E8R, 3EDZ, 3EWJ, 3G42, 3KMC, 3KME, 3L0T, 3L0V, 3LE9, 3LEA, 3LGP, 3O64
Identifiers
Aliases	ADAM17, ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE, ADAM metallopeptidase domain 17
External IDs	OMIM: 603639; MGI: 1096335; HomoloGene: 2395; GeneCards: ADAM17; OMA:ADAM17 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	9,556,732 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	21,423,633 bp
RNA expression pattern
	Top expressed in
	oocyte; ; Achilles tendon; ; pericardium; ; monocyte; ; tendon of biceps brachii; ; sural nerve; ; lower lobe of lung; ; right lung; ; gallbladder; ; upper lobe of lung;
	Top expressed in
	otic vesicle; ; saccule; ; otic placode; ; primary oocyte; ; secondary oocyte; ; cumulus cell; ; genital tubercle; ; tail of embryo; ; stroma of bone marrow; ; left lung lobe;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; interleukin-6 receptor binding; SH3 domain binding; metal ion binding; Notch binding; integrin binding; peptidase activity; protein binding; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; endopeptidase activity;
Cellular component	cytoplasm; integral component of membrane; membrane; cell-cell junction; focal adhesion; plasma membrane; integral component of plasma membrane; ruffle membrane; cell surface; apical plasma membrane; actin cytoskeleton; membrane raft; cytosol;
Biological process	Notch signaling pathway; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of protein phosphorylation; response to hypoxia; T cell differentiation in thymus; cell motility; positive regulation of cell migration; wound healing, spreading of epidermal cells; germinal center formation; tumor necrosis factor-mediated signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; spleen development; proteolysis; positive regulation of leukocyte chemotaxis; positive regulation of cell growth; response to lipopolysaccharide; cell adhesion; cell adhesion mediated by integrin; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; regulation of mast cell apoptotic process; positive regulation of T cell chemotaxis; positive regulation of cell population proliferation; Notch receptor processing; positive regulation of chemokine production; neutrophil mediated immunity; B cell differentiation; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; receptor transactivation; positive regulation of blood vessel endothelial cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity; cellular response to high density lipoprotein particle stimulus; negative regulation of cold-induced thermogenesis; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of vascular endothelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	6868
	11491
	ENSG00000151694
	ENSMUSG00000052593
	P78536
	Q9Z0F8
	NM_003183; NM_001382777; NM_001382778; NM_021832
	NM_001277266; NM_009615; NM_001291871
	NP_003174
	NP_001264195; NP_001278800; NP_033745
	Wikidata
View/Edit Human	View/Edit Mouse

A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases, activated by substrate presentation.