ADCY1

ADCY1
Identifiers
Aliases	ADCY1, AC1, DFNB44, adenylate cyclase 1 (brain), adenylate cyclase 1
External IDs	OMIM: 103072; MGI: 99677; HomoloGene: 41419; GeneCards: ADCY1; OMA:ADCY1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	45,723,116 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	7,128,506 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; orbitofrontal cortex; ; postcentral gyrus; ; superior frontal gyrus; ; Brodmann area 46; ; entorhinal cortex; ; occipital lobe; ; primary visual cortex; ; cerebellar vermis;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; prefrontal cortex; ; primary motor cortex; ; hippocampus proper; ; lateral geniculate nucleus; ; dentate gyrus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; metal ion binding; calmodulin binding; lyase activity; phosphorus-oxygen lyase activity; ATP binding; adenylate cyclase activity; guanylate cyclase activity; calcium- and calmodulin-responsive adenylate cyclase activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; membrane raft; extracellular exosome; nucleus; guanylate cyclase complex, soluble; postsynaptic density; Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	cellular response to calcium ion; activation of protein kinase A activity; intracellular signal transduction; cellular response to forskolin; axonogenesis; rhythmic process; cellular response to glucagon stimulus; cyclic nucleotide biosynthetic process; response to lithium ion; long-term memory; regulation of circadian rhythm; circadian rhythm; renal water homeostasis; activation of adenylate cyclase activity; cAMP biosynthetic process; cGMP biosynthetic process; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cAMP-mediated signaling; G protein-coupled receptor signaling pathway; brain development; positive regulation of CREB transcription factor activity; modulation of chemical synaptic transmission; neuroinflammatory response; positive regulation of long-term synaptic potentiation; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	107
	432530
	ENSG00000164742
	ENSMUSG00000020431
	Q08828
	O88444
	NM_001281768; NM_021116
	NM_009622
	NP_001268697; NP_066939
	NP_033752
	Wikidata
View/Edit Human	View/Edit Mouse

Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.

This gene encodes a form of adenylyl cyclase expressed in the brain. A similar protein in mice is involved in pattern formation of the brain.