ADCY5

ADCY5
Identifiers
Aliases	ADCY5, AC5, FDFM, adenylate cyclase 5, DSKOD
External IDs	OMIM: 600293; MGI: 99673; HomoloGene: 11213; GeneCards: ADCY5; OMA:ADCY5 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	123,449,090 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	35,126,108 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastric mucosa; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; right auricle of heart; ; left ventricle; ; putamen; ; nucleus accumbens; ; cardiac muscle tissue of right atrium;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; ascending aorta; ; globus pallidus; ; superior frontal gyrus; ; nucleus of stria terminalis; ; aortic valve; ; lateral septal nucleus; ; temporal lobe; ; Amygdala;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; adenylate cyclase binding; metal ion binding; lyase activity; protein heterodimerization activity; adenylate cyclase activity; phosphorus-oxygen lyase activity; ATP binding; scaffold protein binding; guanylate cyclase activity;
Cellular component	integral component of membrane; cell projection; membrane; plasma membrane; cilium; intermediate filament cytoskeleton; guanylate cyclase complex, soluble; integral component of plasma membrane;
Biological process	cAMP biosynthetic process; G protein-coupled adenosine receptor signaling pathway; adenylate cyclase-activating dopamine receptor signaling pathway; regulation of insulin secretion involved in cellular response to glucose stimulus; intracellular signal transduction; cellular response to forskolin; adenylate cyclase-activating G protein-coupled receptor signaling pathway; locomotory behavior; neuromuscular process controlling balance; positive regulation of cytosolic calcium ion concentration; cellular response to glucagon stimulus; cyclic nucleotide biosynthetic process; adenylate cyclase-inhibiting dopamine receptor signaling pathway; renal water homeostasis; cGMP biosynthetic process; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; activation of protein kinase A activity;
	Sources:Amigo / QuickGO
Orthologs
	111
	224129
	ENSG00000173175
	ENSMUSG00000022840
	O95622
	P84309
	NM_001199642; NM_183357; NM_001378259
	NM_001012765
	NP_001186571; NP_899200; NP_001365188
	NP_001012783
	Wikidata
View/Edit Human	View/Edit Mouse

Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene.

The human ADCY5 gene is located on the long arm of chromosome 3 and codes for the enzyme Adenylyl Cyclase 5 (AC5). This membrane protein has catalytic activity to convert adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP). In the brain, this enzyme is highly expressed in medium spiny neurons (MSNs) in the striatum. It is also found in non-neuronal cells such as cardiomyocytes and pancreatic islets. AC5 plays a role in several physiological processes including the modulation of neuronal activity particularly in the striatum, thus variants in ADCY5 gene typically lead to movement disorders.