Pituitary adenylate cyclase-activating peptide

ADCYAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GEA, 2D2P, 2JOD
Identifiers
Aliases	ADCYAP1, PACAP, adenylate cyclase activating polypeptide 1
External IDs	OMIM: 102980; MGI: 105094; HomoloGene: 869; GeneCards: ADCYAP1; OMA:ADCYAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	912,172 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	93,513,965 bp
RNA expression pattern
	Top expressed in
	beta cell; ; gonad; ; Hypothalamus; ; prefrontal cortex; ; Brodmann area 9; ; gallbladder; ; cingulate gyrus; ; ganglionic eminence; ; anterior cingulate cortex; ; right frontal lobe;
	Top expressed in
	lumbar spinal ganglion; ; mammillary body; ; ventromedial nucleus; ; ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; trigeminal ganglion; ; habenula; ; central gray substance of midbrain; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	pituitary adenylate cyclase activating polypeptide activity; hormone activity; peptide hormone receptor binding; protein binding; pituitary adenylate cyclase-activating polypeptide receptor binding; neuropeptide hormone activity; signaling receptor binding;
Cellular component	intracellular anatomical structure; extracellular region; terminal bouton; extracellular space; neuron projection; perikaryon; cell body fiber;
Biological process	histamine secretion; pituitary gland development; regulation of G protein-coupled receptor signaling pathway; negative regulation of glial cell proliferation; female pregnancy; cell-cell signaling; negative regulation of cell cycle; negative regulation of muscle cell apoptotic process; behavioral fear response; nervous system development; activation of adenylate cyclase activity; regulation of protein localization; positive regulation of GTPase activity; ATP metabolic process; negative regulation of acute inflammatory response to non-antigenic stimulus; regulation of oligodendrocyte progenitor proliferation; cellular response to glucocorticoid stimulus; positive regulation of gene expression; negative regulation of GTPase activity; positive regulation of synaptic transmission, glutamatergic; positive regulation of chemokine (C-C motif) ligand 5 production; regulation of postsynaptic membrane potential; positive regulation of cell population proliferation; negative regulation of potassium ion transport; positive regulation of ERK1 and ERK2 cascade; positive regulation of interleukin-6 production; positive regulation of neuron projection development; response to starvation; ovarian follicle development; sensory perception of pain; response to ethanol; negative regulation of acute inflammatory response to antigenic stimulus; neuropeptide signaling pathway; neuron projection development; cAMP-mediated signaling; positive regulation of somatostatin secretion; positive regulation of transcription by RNA polymerase II; positive regulation of protein kinase activity; regulation of protein phosphorylation; positive regulation of cytosolic calcium ion concentration; insulin secretion; positive regulation of growth hormone secretion; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cAMP-mediated signaling; brain development; camera-type eye development; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	116
	11516
	ENSG00000141433
	ENSMUSG00000024256
	P18509
	O70176
	NM_001099733; NM_001117
	NM_009625; NM_001315503; NM_001315504
	NP_001093203; NP_001108
	NP_001302432; NP_001302433; NP_033755
	Wikidata
View/Edit Human	View/Edit Mouse

Pituitary adenylate cyclase-activating polypeptide, also known as PACAP, is a protein that in humans is encoded by the ADCYAP1 gene. PACAP is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to vasoactive intestinal peptide receptor and to the pituitary adenylate cyclase-activating polypeptide receptor.