ADD1

ADD1
Identifiers
Aliases	ADD1, ADDA, adducin 1
External IDs	OMIM: 102680; MGI: 87918; HomoloGene: 22758; GeneCards: ADD1; OMA:ADD1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	2,930,076 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	34,789,652 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; tibial nerve; ; right frontal lobe; ; body of uterus; ; right ovary; ; left ovary; ; muscle layer of sigmoid colon; ; sural nerve; ; putamen; ; right lung;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; external carotid artery; ; internal carotid artery; ; primary visual cortex; ; genital tubercle; ; tail of embryo; ; fetal liver hematopoietic progenitor cell; ; granulocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	spectrin binding; protein homodimerization activity; transcription factor binding; structural molecule activity; calmodulin binding; actin filament binding; protein binding; protein heterodimerization activity; actin binding; RNA binding; cadherin binding;
Cellular component	F-actin capping protein complex; cytosol; membrane; focal adhesion; plasma membrane; nucleoplasm; cytoskeleton; nucleus; nuclear body; cytoplasm; postsynaptic density; plasma membrane raft;
Biological process	cell volume homeostasis; multicellular organism growth; barbed-end actin filament capping; in utero embryonic development; actin filament bundle assembly; IRE1-mediated unfolded protein response; transmembrane transport; cell morphogenesis; erythrocyte differentiation; homeostasis of number of cells within a tissue; positive regulation of protein binding; actin cytoskeleton organization; hemoglobin metabolic process; cellular response to calcium ion; positive regulation of establishment of endothelial barrier; positive regulation of adherens junction organization;
	Sources:Amigo / QuickGO
Orthologs
	118
	11518
	ENSG00000087274
	ENSMUSG00000029106
	P35611
	Q9QYC0
NM_001119; NM_001286645; NM_014189; NM_014190; NM_176801;
	NM_001354754; NM_001354755; NM_001354756; NM_001354757; NM_001354759; NM_001354761; NM_001354762; NM_001354758
NM_001024458; NM_001102444; NM_013457; NM_001331080; NM_001331081;
	NM_001331082; NM_001331083; NM_001331084; NM_001331085; NM_001331086; NM_001331087
NP_001110; NP_001273574; NP_054908; NP_054909; NP_789771;
	NP_001341683; NP_001341684; NP_001341685; NP_001341686; NP_001341688; NP_001341690; NP_001341691; NP_001341687
NP_001019629; NP_001095914; NP_001318009; NP_001318010; NP_001318011;
	NP_001318012; NP_001318013; NP_001318014; NP_001318015; NP_001318016; NP_038485
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.