Alpha-1A adrenergic receptor

ADRA1A
Identifiers
Aliases	ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR, adrenoceptor alpha 1A
External IDs	OMIM: 104221; MGI: 104773; HomoloGene: 68078; GeneCards: ADRA1A; OMA:ADRA1A - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	26,867,278 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	67,008,617 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; buccal mucosa cell; ; right lung; ; apex of heart; ; left ventricle; ; right ventricle; ; testicle; ; tail of epididymis; ; upper lobe of left lung; ; spleen;
	Top expressed in
	right kidney; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; brown adipose tissue; ; supraoptic nucleus; ; cerebellar cortex; ; ventricular zone; ; neural tube;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; adrenergic receptor activity; protein heterodimerization activity; G protein-coupled receptor activity; alpha1-adrenergic receptor activity; protein binding;
Cellular component	T-tubule; nuclear membrane; integral component of membrane; nucleus; integral component of plasma membrane; membrane; Z discdkac; plasma membrane; cytoplasm; caveola; dopaminergic synapse; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane;
Biological process	positive regulation of cardiac muscle contraction; negative regulation of cell population proliferation; response to hormone; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of MAPK cascade; intracellular signal transduction; positive regulation of ERK1 and ERK2 cascade; signal transduction; organ growth; cell-cell signaling; positive regulation of smooth muscle contraction; activation of phospholipase C activity; pilomotor reflex; regulation of vasoconstriction; positive regulation of heart rate; positive regulation of synaptic transmission, GABAergic; positive regulation of systemic arterial blood pressure; G protein-coupled receptor signaling pathway; urination; calcium ion transport into cytosol; positive regulation of action potential; positive regulation of the force of heart contraction by epinephrine-norepinephrine; apoptotic process; smooth muscle contraction; phospholipase C-activating G protein-coupled receptor signaling pathway; adenylate cyclase-activating adrenergic receptor signaling pathway; ageing; regulation of cardiac muscle contraction; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of protein kinase C signaling; negative regulation of Rho protein signal transduction; regulation of muscle contraction; adult heart development; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure; positive regulation of cytosolic calcium ion concentration; positive regulation of vasoconstriction; negative regulation of autophagy; positive regulation of cardiac muscle hypertrophy; positive regulation of non-membrane spanning protein tyrosine kinase activity; cell growth involved in cardiac muscle cell development; regulation of synaptic vesicle exocytosis; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; neuron-glial cell signaling;
	Sources:Amigo / QuickGO
Orthologs
	148
	11549
	ENSG00000120907
	ENSMUSG00000045875
	P35348
	P97718
NM_000680; NM_033302; NM_033303; NM_033304; NM_001322502;
	NM_001322503; NM_001322504
	NM_001271759; NM_001271760; NM_001271761; NM_013461
NP_000671; NP_001309431; NP_001309432; NP_001309433; NP_150645;
	NP_150646; NP_150647
	NP_001258688; NP_001258689; NP_001258690; NP_038489
	Wikidata
View/Edit Human	View/Edit Mouse

The alpha-1A adrenergic receptor (α_1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. There is no longer a subtype α_1C receptor. At one time, there was a subtype known as α_1C, but it was found to be identical to the previously discovered α_1A receptor subtype. To avoid confusion, the naming convention was continued with the letter D.