Beta-3 adrenergic receptor

ADRB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CDW
Identifiers
Aliases	ADRB3, BETA3AR, adrenoceptor beta 3
External IDs	OMIM: 109691; MGI: 87939; HomoloGene: 37250; GeneCards: ADRB3; OMA:ADRB3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	37,966,599 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,250,616 bp
RNA expression pattern
	Top expressed in
	right ovary; ; left ovary; ; testicle; ; left uterine tube; ; placenta; ; urinary bladder; ; gallbladder; ; gonad; ; muscle layer of sigmoid colon; ; fundus;
	Top expressed in
	lactiferous gland; ; white adipose tissue; ; brown adipose tissue; ; tunica adventitia of aorta; ; subcutaneous adipose tissue; ; intercostal muscle; ; tunica media of zone of aorta; ; trachea; ; mesenteric lymph nodes; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	beta-adrenergic receptor activity; G protein-coupled receptor activity; epinephrine binding; protein homodimerization activity; beta3-adrenergic receptor activity; norepinephrine binding; beta-3 adrenergic receptor binding; signal transducer activity; adrenergic receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; receptor complex; plasma membrane; integral component of plasma membrane; nucleus;
Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway; eating behavior; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; response to antibiotic; negative regulation of multicellular organism growth; cell-cell signaling; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; ageing; receptor-mediated endocytosis; generation of precursor metabolites and energy; activation of adenylate cyclase activity; diet induced thermogenesis; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; adenylate cyclase-activating adrenergic receptor signaling pathway; heat generation; brown fat cell differentiation; response to cold; energy reserve metabolic process; temperature homeostasis; desensitization of G protein-coupled receptor signaling pathway by arrestin; positive regulation of MAPK cascade; signal transduction; carbohydrate metabolic process; G protein-coupled receptor signaling pathway; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	155
	11556
	ENSG00000188778
	ENSMUSG00000031489
	P13945
	P25962
	NM_000025
	NM_013462
	NP_000016
	NP_038490
	Wikidata
View/Edit Human	View/Edit Mouse

The beta-3 adrenergic receptor (β₃-adrenoceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the human gene encoding it.