AEBP2

AEBP2
Identifiers
Aliases	AEBP2, AE binding protein 2
External IDs	OMIM: 617934; MGI: 1338038; HomoloGene: 40690; GeneCards: AEBP2; OMA:AEBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	19,720,801 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	140,624,198 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; retinal pigment epithelium; ; skin of arm; ; caput epididymis; ; pancreatic epithelial cell; ; buccal mucosa cell; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; tail of epididymis; ; gingival epithelium;
	Top expressed in
	condyle; ; fossa; ; Paneth cell; ; medullary collecting duct; ; renal corpuscle; ; saccule; ; vestibular membrane of cochlear duct; ; ciliary body; ; endothelial cell of lymphatic vessel; ; otic placode;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; transcription corepressor activity; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; ESC/E(Z) complex; nucleoplasm;
Biological process	negative regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	121536
	11569
	ENSG00000139154
	ENSMUSG00000030232
	Q6ZN18
	Q9Z248
	NM_001114176; NM_001267043; NM_153207; NM_001363736
	NM_001005605; NM_009637; NM_178803; NM_001309436; NM_001309437
	NP_001107648; NP_001253972; NP_694939; NP_001350665
	NP_001005605; NP_001296365; NP_001296366; NP_033767; NP_848918
	Wikidata
View/Edit Human	View/Edit Mouse

Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. It was initially identified due to its binding capability to the promoter of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2).