AFAP1

AFAP1
Identifiers
Aliases	AFAP1, AFAP, AFAP-110, AFAP110, actin filament associated protein 1
External IDs	OMIM: 608252; MGI: 1917542; HomoloGene: 11009; GeneCards: AFAP1; OMA:AFAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	7,939,926 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	36,161,267 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; sural nerve; ; right testis; ; left testis; ; ganglionic eminence; ; muscle layer of sigmoid colon; ; epithelium of colon; ; popliteal artery; ; tibial arteries; ; testicle;
	Top expressed in
	pineal gland; ; decidua; ; iris; ; umbilical cord; ; aorta; ; superior cervical ganglion; ; otolith organ; ; calvaria; ; utricle; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; SH3 domain binding; SH2 domain binding;
Cellular component	cytoplasm; cytoskeleton; focal adhesion; cytosol; actin cytoskeleton;
Biological process	regulation of signal transduction; regulation of cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	60312
	70292
	ENSG00000196526
	ENSMUSG00000029094
	Q8N556
	Q80YS6
	NM_001134647; NM_021638; NM_198595; NM_001371090; NM_001371091
	NM_027373
	NP_001128119; NP_940997; NP_001358019; NP_001358020
	NP_081649; NP_001390348; NP_001390349; NP_001390350
	Wikidata
View/Edit Human	View/Edit Mouse

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.