AGK (gene)

AGK
Identifiers
Aliases	AGK, CATC5, CTRCT38, MTDPS10, MULK, acylglycerol kinase
External IDs	OMIM: 610345; MGI: 1917173; HomoloGene: 41239; GeneCards: AGK; OMA:AGK - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	141,655,244 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	40,373,696 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; Brodmann area 9; ; prefrontal cortex; ; islet of Langerhans; ; bone marrow cells; ; right frontal lobe; ; epithelium of colon; ; Achilles tendon; ; smooth muscle tissue;
	Top expressed in
	zygote; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; right kidney; ; yolk sac; ; tail of embryo; ; primary visual cortex; ; superior frontal gyrus; ; ventricular zone; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; ceramide kinase activity; nucleotide binding; lipid kinase activity; diacylglycerol kinase activity; ATP binding; acylglycerol kinase activity; kinase activity; NAD+ kinase activity;
Cellular component	mitochondrial outer membrane; intracellular membrane-bounded organelle; mitochondrion; membrane; cytosol; integral component of mitochondrial inner membrane; TIM22 mitochondrial import inner membrane insertion complex; mitochondrial inner membrane; mitochondrial intermembrane space;
Biological process	glycerolipid metabolic process; ceramide biosynthetic process; lipid phosphorylation; phosphorylation; metabolism; glycerophospholipid biosynthetic process; protein insertion into mitochondrial inner membrane;
	Sources:Amigo / QuickGO
Orthologs
	55750
	69923
	ENSG00000006530; ENSG00000262327
	ENSMUSG00000029916
	Q53H12
	Q9ESW4
	NM_018238; NM_001364948
	NM_023538
	NP_060708
	NP_076027
	Wikidata
View/Edit Human	View/Edit Mouse

The human gene AGK encodes the enzyme mitochondrial acylglycerol kinase.

The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. It catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10.

Diseases associated with AGK include cataracts and cardiomyopathy. An important paralog of this gene is CERKL.