AGR2

AGR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LNS, 2LNT
Identifiers
Aliases	AGR2, AG2, GOB-4, HAG-2, HEL-S-116, PDIA17, XAG-2, anterior gradient 2, protein disulphide isomerase family member, AG-2, HPC8
External IDs	OMIM: 606358; MGI: 1344405; HomoloGene: 4674; GeneCards: AGR2; OMA:AGR2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	16,833,433 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	36,054,086 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; pylorus; ; nasal epithelium; ; rectum; ; bronchial epithelial cell; ; palpebral conjunctiva; ; mucosa of transverse colon; ; corpus epididymis; ; right uterine tube; ; olfactory zone of nasal mucosa;
	Top expressed in
	pyloric antrum; ; Ileal epithelium; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach; ; left colon; ; olfactory epithelium; ; Paneth cell; ; duodenum; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	epidermal growth factor receptor binding; protein binding; protein homodimerization activity; dystroglycan binding;
Cellular component	extracellular region; endoplasmic reticulum; extracellular space;
Biological process	positive regulation of PERK-mediated unfolded protein response; response to endoplasmic reticulum stress; positive regulation of IRE1-mediated unfolded protein response; positive regulation of gene expression; positive regulation of developmental growth; negative regulation of cell death; positive regulation of epidermal growth factor receptor signaling pathway; lung goblet cell differentiation; digestive tract morphogenesis; mucus secretion; positive regulation of cell-substrate adhesion; cell differentiation; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	10551
	23795
	ENSG00000106541
	ENSMUSG00000020581
	O95994
	O88312
	NM_006408
	NM_011783
	NP_006399
	NP_035913
	Wikidata
View/Edit Human	View/Edit Mouse

Anterior gradient protein 2 homolog (AGR-2), also known as secreted cement gland protein XAG-2 homolog, is a protein that in humans is encoded by the AGR2 gene. Anterior gradient homolog 2 was originally discovered in Xenopus laevis. In Xenopus AGR2 plays a role in cement gland differentiation, but in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response, cell migration, and cell transformation. However, there have been other observations that AGR2 can repress growth and proliferation.