AGXT

AGXT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H0C, 1J04, 2YOB, 3R9A, 4CBR, 4CBS, 4I8A, 4KXK, 4KYO
Identifiers
Aliases	AGXT, AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6, alanine-glyoxylate aminotransferase, alanine--glyoxylate and serine--pyruvate aminotransferase, Ser-PyrAT
External IDs	OMIM: 604285; MGI: 1329033; HomoloGene: 37251; GeneCards: AGXT; OMA:AGXT - orthologs
EC number	2.6.1.44
Gene location (Human)
Chr.	Chromosome 2 (human)
End	240,880,502 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,073,143 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; buccal mucosa cell; ; cartilage tissue; ; human kidney; ; testicle; ; kidney tubule; ; cerebellar vermis; ; gonad; ; renal medulla; ; renal cortex;
	Top expressed in
	left lobe of liver; ; embryo; ; gallbladder; ; sexually immature organism; ; gastrula; ; duodenum; ; jejunum; ; Ileal epithelium; ; CA3 field; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein homodimerization activity; amino acid binding; alanine-glyoxylate transaminase activity; serine-pyruvate transaminase activity; transaminase activity; protein self-association; catalytic activity; protein binding; pyridoxal phosphate binding; signaling receptor binding; identical protein binding;
Cellular component	peroxisome; mitochondrial matrix; peroxisomal matrix; mitochondrion; intracellular membrane-bounded organelle; cytosol;
Biological process	Notch signaling pathway; oxalic acid secretion; glyoxylate catabolic process; glycine biosynthetic process, by transamination of glyoxylate; pyruvate biosynthetic process; L-alanine catabolic process; response to glucocorticoid; response to cAMP; L-cysteine catabolic process; cellular nitrogen compound metabolic process; glyoxylate metabolic process; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	189
	11611
	ENSG00000172482
	ENSMUSG00000026272
	P21549
	O35423
	NM_000030
	NM_001276710; NM_016702
	NP_000021
	NP_001263639; NP_057911
	Wikidata
View/Edit Human	View/Edit Mouse

Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene.

This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targeting, have been associated with type I primary hyperoxaluria.