Allograft inflammatory factor 1

AIF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D58, 2G2B
Identifiers
Aliases	AIF1, AIF-1, IBA1, IRT-1, IRT1, allograft inflammatory factor 1, Iba-1
External IDs	OMIM: 601833; MGI: 1343098; HomoloGene: 1226; GeneCards: AIF1; OMA:AIF1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,617,021 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,395,044 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; bone marrow cells; ; testicle; ; right lung; ; gallbladder; ; C1 segment; ; rectum; ; spleen; ; right coronary artery;
	Top expressed in
	seminiferous tubule; ; mesenteric lymph nodes; ; spermatid; ; spleen; ; stroma of bone marrow; ; thymus; ; spermatocyte; ; subcutaneous adipose tissue; ; optic nerve; ; aortic valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; actin filament binding; actin binding; molecular function;
Cellular component	cytoplasm; cytosol; perikaryon; cell projection; membrane; ruffle; plasma membrane; ruffle membrane; actin filament; perinuclear region of cytoplasm; phagocytic cup; cytoskeleton; nucleus; lamellipodium;
Biological process	cellular response to extracellular stimulus; positive regulation of smooth muscle cell chemotaxis; response to cytokine; positive regulation of protein phosphorylation; negative regulation of smooth muscle cell proliferation; positive regulation of cell migration; positive regulation of muscle hyperplasia; positive regulation of nitric oxide biosynthetic process; positive regulation of monocyte chemotaxis; negative regulation of apoptotic process; response to glucocorticoid; response to electrical stimulus; negative regulation of gene expression; cellular response to hydroperoxide; actin filament bundle assembly; microglial cell activation; positive regulation of G1/S transition of mitotic cell cycle; actin filament polymerization; negative regulation of smooth muscle cell chemotaxis; cellular response to hormone stimulus; phagocytosis, engulfment; response to axon injury; positive regulation of T cell proliferation; cellular response to interferon-gamma; cellular response to morphine; Rac protein signal transduction; inflammatory response; ruffle assembly; positive regulation of T cell migration; positive regulation of smooth muscle cell proliferation; cerebellum development; positive regulation of cell population proliferation; regulation of gene expression; parallel actin filament bundle assembly; cellular response to oxidative stress; positive regulation of chemotaxis; actin crosslink formation; positive regulation of mononuclear cell migration; positive regulation of fibroblast growth factor production;
	Sources:Amigo / QuickGO
Orthologs
	199
	11629
ENSG00000206428; ENSG00000235985; ENSG00000235588; ENSG00000234836; ENSG00000237727;
	ENSG00000204472
	ENSMUSG00000024397
	P55008; Q4V347
	O70200
	NM_001623; NM_004847; NM_032955; NM_001318970
	NM_019467; NM_001361501; NM_001361502
	NP_001305899; NP_001614; NP_116573; NP_001614.3
	NP_062340; NP_001348430; NP_001348431
	Wikidata
View/Edit Human	View/Edit Mouse

Allograft inflammatory factor 1 (AIF-1) also known as ionized calcium-binding adapter molecule 1 (IBA1) is a protein that in humans is encoded by the AIF1 gene.