Allograft inflammatory factor 1-like

AIF1L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JJZ, 2VTG
Identifiers
Aliases	AIF1L, C9orf58, IBA2, allograft inflammatory factor 1 like
External IDs	MGI: 1919598; HomoloGene: 12863; GeneCards: AIF1L; OMA:AIF1L - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	131,123,152 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	31,863,454 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; C1 segment; ; inferior ganglion of vagus nerve; ; human kidney; ; spleen; ; internal globus pallidus; ; ventral tegmental area; ; Medulla Oblongata; ; ventricular zone; ; substantia nigra;
	Top expressed in
	decidua; ; stria vascularis; ; cumulus cell; ; ciliary body; ; subiculum; ; Region I of hippocampus proper; ; retinal pigment epithelium; ; maxillary prominence; ; piriform cortex; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; actin filament binding; actin binding; metal ion binding;
Cellular component	cytoplasm; actin cytoskeleton; ruffle membrane; plasma membrane; cell projection; extracellular exosome; cytoskeleton; membrane; focal adhesion; actin filament; protein-containing complex;
Biological process	actin filament bundle assembly; ruffle assembly;
	Sources:Amigo / QuickGO
Orthologs
	83543
	108897
	ENSG00000126878
	ENSMUSG00000001864
	Q9BQI0
	Q9EQX4
	NM_001002260; NM_001185095; NM_001185096; NM_031426
	NM_145144
	NP_001172024; NP_001172025; NP_113614
	NP_660126
	Wikidata
View/Edit Human	View/Edit Mouse

Allograft inflammatory factor 1-like is a protein that is encoded by the AIF1L gene in humans.

AIF1L is an actin-binding protein that promotes actin bundling. It may neither bind calcium nor depend on calcium for function. It has biased expression in kidney (RPKM 130.1), spleen (RPKM 121.3) and 8 other tissues.