AIFM2

AIFM2
Identifiers
Aliases	AIFM2, AMID, PRG3, apoptosis inducing factor, mitochondria associated 2, apoptosis inducing factor mitochondria associated 2, FSP1
External IDs	OMIM: 605159; MGI: 1918611; HomoloGene: 6862; GeneCards: AIFM2; OMA:AIFM2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	70,132,934 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	61,575,039 bp
RNA expression pattern
	Top expressed in
	adipose tissue; ; subcutaneous adipose tissue; ; abdominal fat; ; mucosa of transverse colon; ; apex of heart; ; left ventricle; ; right lobe of thyroid gland; ; left coronary artery; ; left lobe of thyroid gland; ; right lobe of liver;
	Top expressed in
	brown adipose tissue; ; white adipose tissue; ; adrenal gland; ; subcutaneous adipose tissue; ; intercostal muscle; ; adrenal medulla; ; mammary gland; ; lumbar subsegment of spinal cord; ; urinary bladder; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	electron-transferring-flavoprotein dehydrogenase activity; DNA binding; oxidoreductase activity; flavin adenine dinucleotide binding;
Cellular component	cytoplasm; integral component of membrane; cytosol; lipid droplet; membrane; mitochondrion; mitochondrial outer membrane; extracellular space;
Biological process	apoptotic process; apoptotic mitochondrial changes; positive regulation of apoptotic process; regulation of apoptotic process; respiratory electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	84883
	71361
	ENSG00000042286
	ENSMUSG00000020085
	Q9BRQ8
	Q8BUE4
	NM_032797; NM_001198696
	NM_001039194; NM_001284300; NM_153779; NM_178058
	NP_001185625; NP_116186
	NP_001034283; NP_001271229; NP_722474; NP_835159
	Wikidata
View/Edit Human	View/Edit Mouse

Apoptosis-inducing factor 2 (AIFM2), also known as ferroptosis suppressor protein 1 (FSP1), apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID), is a protein that in humans is encoded by the AIFM2 gene, also known as p53-responsive gene 3 (PRG3), on chromosome 10.

This gene encodes a flavoprotein oxidoreductase that reduces coenzyme Q10, vitamin E, and vitamin K.