AKAP4

AKAP4
Identifiers
Aliases	AKAP4, AKAP 82, AKAP-4, AKAP82, CT99, FSC1, HI, PRKA4, hAKAP82, p82, A-kinase anchoring protein 4
External IDs	OMIM: 300185; MGI: 102794; HomoloGene: 2887; GeneCards: AKAP4; OMA:AKAP4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	50,201,007 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	6,944,848 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; testicle; ; buccal mucosa cell; ; tail of epididymis; ; caput epididymis; ; female breast; ; mammary gland; ; lactiferous gland;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; lumbar spinal ganglion; ; gastrula; ; islet of Langerhans; ; primitive streak; ; telencephalic nucleus; ; basal forebrain; ; midbrain tegmentum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase A binding; protein binding;
Cellular component	cytoplasm; cell projection; cilium; sperm fibrous sheath; sperm principal piece; Z discdkac; perinuclear region of cytoplasm; cAMP-dependent protein kinase complex; motile cilium; cytoskeleton; nucleus;
Biological process	flagellated sperm motility; protein localization; establishment of protein localization; regulation of protein kinase A signaling; single fertilization; transmembrane receptor protein serine/threonine kinase signaling pathway; cell projection organization; motile cilium assembly; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	8852
	11643
	ENSG00000147081
	ENSMUSG00000050089
	Q5JQC9
	Q60662
	NM_139289; NM_003886
	NM_001042542; NM_009651
	NP_003877; NP_647450
	NP_001036007; NP_033781
	Wikidata
View/Edit Human	View/Edit Mouse

A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene. It involves in the intracellular signalling of protein kinase -A. AKAP4 is called as cancer /testis antigen (CTA), it belongs to a class of tumour linked antigens categories by high expression in germ cells and cancer than normal tissues. AKAP4 is not normally expressed in mRNA and protein level in MM cell line.