AKR1B10

AKR1B10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZUA, 4GA8, 4GAB, 4GQ0, 4GQG, 4I5X, 4ICC, 4JIH, 4JII, 4WEV, 4XZL, 4XZN, 4XZM
Identifiers
Aliases	AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI, aldo-keto reductase family 1, member B10 (aldose reductase), aldo-keto reductase family 1 member B10
External IDs	OMIM: 604707; MGI: 107673; HomoloGene: 116462; GeneCards: AKR1B10; OMA:AKR1B10 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	134,541,412 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	34,345,398 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of ileum; ; gums; ; gingival epithelium; ; mucosa of transverse colon; ; gallbladder; ; pancreatic ductal cell; ; gastric mucosa; ; islet of Langerhans; ; mucosa of sigmoid colon;
	Top expressed in
	pyloric antrum; ; mucous cell of stomach; ; adrenal gland; ; Scarpa's ganglion; ; epithelium of stomach; ; blastocyst; ; endothelial cell of lymphatic vessel; ; Gonadal ridge; ; stroma of bone marrow; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	retinal dehydrogenase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; aldo-keto reductase (NADP) activity; protein binding; oxidoreductase activity; alditol:NADP+ 1-oxidoreductase activity; alcohol dehydrogenase (NADP+) activity; NADP-retinol dehydrogenase activity; allyl-alcohol dehydrogenase activity;
Cellular component	cytosol; extracellular region; lysosome; mitochondrion;
Biological process	daunorubicin metabolic process; doxorubicin metabolic process; retinoid metabolic process; farnesol catabolic process; retinol metabolic process; cellular detoxification of aldehyde;
	Sources:Amigo / QuickGO
Orthologs
	57016
	14187
	ENSG00000198074
	ENSMUSG00000029762
	O60218
	P45377
	NM_020299
	NM_008012
	NP_064695
	NP_032038
	Wikidata
View/Edit Human	View/Edit Mouse

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.