Delta-aminolevulinic acid dehydratase

ALAD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E51, 1PV8, 5HNR, 5HMS
Identifiers
Aliases	ALAD, ALADH, PBGS, aminolevulinate dehydratase, ALA dehydratase
External IDs	OMIM: 125270; MGI: 96853; HomoloGene: 16; GeneCards: ALAD; OMA:ALAD - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	113,401,290 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	62,438,155 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; C1 segment; ; inferior olivary nucleus; ; dorsal motor nucleus of vagus nerve; ; parotid gland; ; trabecular bone; ; right lobe of liver;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; vestibular membrane of cochlear duct; ; epithelium of lens; ; left lobe of liver; ; vestibular sensory epithelium; ; human fetus; ; corneal stroma; ; right kidney; ; yolk sac; ; efferent ductule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	porphobilinogen synthase activity; zinc ion binding; metal ion binding; catalytic activity; lyase activity; identical protein binding; proteasome core complex binding;
Cellular component	cytosol; extracellular exosome; nucleus; extracellular region; extracellular space; secretory granule lumen; ficolin-1-rich granule lumen; proteasome core complex;
Biological process	cellular response to interleukin-4; response to ionizing radiation; response to platinum ion; response to selenium ion; response to amino acid; cellular response to lead ion; response to hypoxia; response to cadmium ion; response to fatty acid; response to vitamin B1; response to organic cyclic compound; response to vitamin; response to nutrient; response to metal ion; response to zinc ion; response to glucocorticoid; response to arsenic-containing substance; protoporphyrinogen IX biosynthetic process; response to oxidative stress; response to organic substance; response to activity; tetrapyrrole biosynthetic process; porphyrin-containing compound biosynthetic process; response to vitamin E; response to iron ion; heme biosynthetic process; response to lipopolysaccharide; response to nutrient levels; response to lead ion; response to inorganic substance; response to aluminum ion; response to hormone; response to mercury ion; metabolism; response to methylmercury; response to ethanol; response to cobalt ion; protein homooligomerization; response to toxic substance; response to herbicide; neutrophil degranulation; negative regulation of proteasomal protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	210
	17025
	ENSG00000148218
	ENSMUSG00000028393
	P13716
	P10518
	NM_000031; NM_001003945; NM_001317745
	NM_001276446; NM_008525
	NP_000022; NP_001003945; NP_001304674
	NP_001263375; NP_032551
	Wikidata
View/Edit Human	View/Edit Mouse

Aminolevulinic acid dehydratase (porphobilinogen synthase, or ALA dehydratase, or aminolevulinate dehydratase) is an enzyme (EC 4.2.1.24) that in humans is encoded by the ALAD gene. Porphobilinogen synthase (or ALA dehydratase, or aminolevulinate dehydratase) synthesizes porphobilinogen through the asymmetric condensation of two molecules of aminolevulinic acid. All natural tetrapyrroles, including hemes, chlorophylls and vitamin B₁₂, share porphobilinogen as a common precursor. Porphobilinogen synthase is the prototype morpheein.