ALCAM

ALCAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A2F
Identifiers
Aliases	ALCAM, CD166, MEMD, activated leukocyte cell adhesion molecule
External IDs	OMIM: 601662; MGI: 1313266; HomoloGene: 1229; GeneCards: ALCAM; OMA:ALCAM - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	105,576,900 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	52,274,437 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; mucosa of paranasal sinus; ; endothelial cell; ; palpebral conjunctiva; ; pars reticulata; ; corpus callosum; ; visceral pleura; ; external globus pallidus; ; pars compacta; ; trigeminal ganglion;
	Top expressed in
	olfactory tubercle; ; vas deferens; ; right lung lobe; ; left lung lobe; ; stria vascularis; ; nucleus accumbens; ; anterior amygdaloid area; ; globus pallidus; ; ventromedial nucleus; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; signaling receptor binding; identical protein binding;
Cellular component	integral component of membrane; cell projection; membrane; focal adhesion; intrinsic component of plasma membrane; plasma membrane; integral component of plasma membrane; T cell receptor complex; extracellular region; axon; soma; dendrite; immunological synapse; extracellular exosome; external side of plasma membrane;
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; adaptive immune response; immune system process; neuron projection extension; cell adhesion; motor neuron axon guidance; axon extension involved in axon guidance; signal transduction; retinal ganglion cell axon guidance; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	214
	11658
	ENSG00000170017
	ENSMUSG00000022636
	Q13740
	Q61490
	NM_001627; NM_001243280; NM_001243281; NM_001243283
	NM_009655; NM_001331110
	NP_001230209; NP_001230210; NP_001230212; NP_001618
	NP_001318039; NP_033785
	Wikidata
View/Edit Human	View/Edit Mouse

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene. It is also called CD166 (cluster of differentiation 166), MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands. CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanom--a. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.

Recently, CD166 has also been used as a potential cancer stem cell marker.