Aldolase C

ALDOC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XFB
Identifiers
Aliases	ALDOC, ALDC, Aldolase C, aldolase, fructose-bisphosphate C
External IDs	OMIM: 103870; MGI: 101863; HomoloGene: 21073; GeneCards: ALDOC; OMA:ALDOC - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,576,948 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,218,607 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; Pons; ; right frontal lobe; ; lateral nuclear group of thalamus; ; Amygdala; ; nucleus accumbens; ; cingulate gyrus; ; Brodmann area 9; ; anterior cingulate cortex; ; superior vestibular nucleus;
	Top expressed in
	cerebellar vermis; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; dorsal tegmental nucleus; ; lobe of cerebellum; ; central gray substance of midbrain; ; pontine nuclei; ; motor neuron; ; corpora quadrigemina; ; inferior colliculi;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding; protein binding; catalytic activity; lyase activity; fructose-bisphosphate aldolase activity;
Cellular component	cytosol; extracellular exosome; cytoskeleton; mitochondrion; extracellular region; secretory granule lumen; tertiary granule lumen; ficolin-1-rich granule lumen;
Biological process	gluconeogenesis; fructose metabolic process; glycolytic process; epithelial cell differentiation; canonical glycolysis; fructose 1,6-bisphosphate metabolic process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	230
	11676
	ENSG00000109107
	ENSMUSG00000017390
	P09972
	P05063
	NM_005165
	NM_009657; NM_001303423
	NP_005156
	NP_001290352; NP_033787
	Wikidata
View/Edit Human	View/Edit Mouse

Aldolase C, fructose-bisphosphate (ALDOC, or ALDC), is an enzyme that, in humans, is encoded by the ALDOC gene on chromosome 17. This gene encodes a member of the class I fructose-bisphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose 1,6-bisphosphate and fructose-1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde 3-phosphate or glyceraldehyde, respectively.