ALG2

ALG2
Identifiers
Aliases	ALG2, CDGIi, NET38, hALPG2, CMS14, CMSTA3, alpha-1,3/1,6-mannosyltransferase, CDG1I, ALG2 alpha-1,3/1,6-mannosyltransferase
External IDs	OMIM: 607905; MGI: 1914731; HomoloGene: 5930; GeneCards: ALG2; OMA:ALG2 - orthologs
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	47,474,333 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; corpus epididymis; ; caput epididymis; ; secondary oocyte; ; germinal epithelium; ; tibia; ; islet of Langerhans; ; body of pancreas; ; visceral pleura; ; parietal pleura;
	Top expressed in
	median eminence; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; supraoptic nucleus; ; arcuate nucleus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; suprachiasmatic nucleus; ; habenula; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity; transferase activity; protein N-terminus binding; protein heterodimerization activity; glycosyltransferase activity; protein binding; calcium-dependent protein binding; alpha-1,3-mannosyltransferase activity; GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity;
Cellular component	cytoplasm; integral component of membrane; nucleus; membrane; perinuclear region of cytoplasm; endoplasmic reticulum membrane; cytosol; actin cytoskeleton;
Biological process	response to calcium ion; protein glycosylation; dolichol-linked oligosaccharide biosynthetic process; mannosylation; oligosaccharide-lipid intermediate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	85365
	56737
	n/a
	ENSMUSG00000039740
	Q9H553
	Q9DBE8
	NM_033087; NM_197973
	NM_019998; NM_001355496
	NP_149078
	NP_064382; NP_001342425
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,3/1,6-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene. Mutations in the human gene are associated with congenital defects in glycosylation The protein encoded by the ALG2 gene belongs to two classes of enzymes: GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase (EC 2.4.1.132) and GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase (EC 2.4.1.257).