ALG3

ALG3
Identifiers
Aliases	ALG3, CDG1D, CDGS4, D16Ertd36e, NOT56L, Not56, CDGS6, not, alpha-1,3- mannosyltransferase, ALG3 alpha-1,3- mannosyltransferase
External IDs	OMIM: 608750; MGI: 1098592; HomoloGene: 4228; GeneCards: ALG3; OMA:ALG3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	184,249,548 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	20,430,485 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; stromal cell of endometrium; ; right lobe of liver; ; right adrenal gland; ; body of pancreas; ; left adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; gonad; ; granulocyte;
	Top expressed in
	otic placode; ; tail of embryo; ; otic vesicle; ; choroid plexus of fourth ventricle; ; genital tubercle; ; embryo; ; saccule; ; embryo; ; yolk sac; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; hexosyltransferase activity; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity; alpha-1,3-mannosyltransferase activity; protein binding; mannosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; integral component of endoplasmic reticulum membrane;
Biological process	protein glycosylation; dolichol-linked oligosaccharide biosynthetic process; mannosylation;
	Sources:Amigo / QuickGO
Orthologs
	10195
	208624
	ENSG00000214160
	ENSMUSG00000033809
	Q92685
	Q8K2A8
	NM_001006940; NM_001006941; NM_005787
	NM_145939; NM_001357403; NM_001357404; NM_001357405; NM_001357406
	NP_001006942; NP_005778
	NP_666051; NP_001344332; NP_001344333; NP_001344334; NP_001344335
	Wikidata
View/Edit Human	View/Edit Mouse

Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase is an enzyme that, in humans, is encoded by the ALG3 gene.

This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation.