ALG8

ALG8
Identifiers
Aliases	ALG8, CDG1H, alpha-1,3-glucosyltransferase, PCLD3, ALG8 alpha-1,3-glucosyltransferase
External IDs	OMIM: 608103; MGI: 2141959; HomoloGene: 6931; GeneCards: ALG8; OMA:ALG8 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	78,139,660 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	97,041,392 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; epithelium of colon; ; ventricular zone; ; testicle; ; right lobe of liver; ; right adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; stromal cell of endometrium;
	Top expressed in
	tail of embryo; ; genital tubercle; ; spermatocyte; ; yolk sac; ; Paneth cell; ; otic vesicle; ; ventricular zone; ; endothelial cell of lymphatic vessel; ; zygote; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; hexosyltransferase activity; alpha-1,3-mannosyltransferase activity; dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity; protein binding; dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	protein glycosylation; dolichol-linked oligosaccharide biosynthetic process; protein N-linked glycosylation; oligosaccharide-lipid intermediate biosynthetic process; mannosylation; protein N-linked glycosylation via asparagine;
	Sources:Amigo / QuickGO
Orthologs
	79053
	381903
	ENSG00000159063
	ENSMUSG00000035704
	Q9BVK2
	Q6P8H8
	NM_001007027; NM_001007028; NM_024079
	NM_199035
	NP_001007028; NP_076984
	NP_950200
	Wikidata
View/Edit Human	View/Edit Mouse

Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase is an enzyme encoded in humans by the ALG8 gene.

This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified.