ALOX12

ALOX12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D3L
Identifiers
Aliases	ALOX12, 12-LOX, 12S-LOX, LOG12, arachidonate 12-lipoxygenase, 12S type
External IDs	OMIM: 152391; MGI: 87998; HomoloGene: 560; GeneCards: ALOX12; OMA:ALOX12 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,010,754 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,146,179 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; buccal mucosa cell; ; monocyte; ; epithelium of esophagus; ; gonad; ; gums; ; vagina; ; oral cavity; ; skin of abdomen; ; skin of leg;
	Top expressed in
	blood; ; efferent ductule; ; conjunctival fornix; ; tibiofemoral joint; ; transitional epithelium of urinary bladder; ; submandibular gland; ; ankle joint; ; lip; ; seminal vesicula; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hepoxilin A3 synthase activity; iron ion binding; arachidonate 12(S)-lipoxygenase activity; dioxygenase activity; hepoxilin-epoxide hydrolase activity; metal ion binding; protein binding; linoleate 13S-lipoxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; hydrolase activity;
Cellular component	cytoplasm; cytosol; membrane; sarcolemma; extracellular exosome;
Biological process	linoleic acid metabolic process; positive regulation of cell death; positive regulation of endothelial cell differentiation; establishment of skin barrier; lipoxin A4 biosynthetic process; lipid metabolism; positive regulation of cell migration; lipoxin B4 biosynthetic process; ageing; negative regulation of apoptotic process; negative regulation of platelet aggregation; negative regulation of muscle cell apoptotic process; fatty acid metabolic process; positive regulation of angiogenesis; reactive oxygen species metabolic process; superoxide anion generation; positive regulation of endothelial cell migration; lipoxygenase pathway; hepoxilin biosynthetic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cell growth; positive regulation of gene expression; leukotriene A4 metabolic process; positive regulation of mitochondrial depolarization; fatty acid oxidation; positive regulation of cell population proliferation; positive regulation of apoptotic process; cellular response to lipid; hepoxilin metabolic process; lipoxin metabolic process; positive regulation of cell adhesion; positive regulation of smooth muscle cell proliferation; arachidonic acid metabolic process; long-chain fatty acid biosynthetic process; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial tube morphogenesis; lipoxin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	239
	11684
	ENSG00000108839
	ENSMUSG00000000320
	P18054
	P39655
	NM_000697
	NM_007440; NM_001331118
	NP_000688
	NP_001318047; NP_031466
	Wikidata
View/Edit Human	View/Edit Mouse

ALOX12 (EC 1.13.11.31), also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans is encoded by the ALOX12 gene which is located along with other lipoyxgenases on chromosome 17p13.3. ALOX12 is 75 kilodalton protein composed of 663 amino acids.