ALOX12B

ALOX12B
Identifiers
Aliases	ALOX12B, 12R-LOX, ARCI2, arachidonate 12-lipoxygenase, 12R type
External IDs	OMIM: 603741; MGI: 1274782; HomoloGene: 884; GeneCards: ALOX12B; OMA:ALOX12B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,087,716 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,060,618 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; human penis; ; skin of thigh; ; vulva; ; skin of arm; ; gingival epithelium; ; cervix epithelium; ; skin of hip; ; nipple;
	Top expressed in
	esophagus; ; superior surface of tongue; ; lip; ; umbilical cord; ; skin of external ear; ; skin of back; ; embryo; ; skin of abdomen; ; yolk sac; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; arachidonate 12(S)-lipoxygenase activity; dioxygenase activity; metal ion binding; protein binding; catalytic activity; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; linoleate 9S-lipoxygenase activity;
Cellular component	cytoplasm; cytosol;
Biological process	linoleic acid metabolic process; establishment of skin barrier; lipid metabolism; ceramide biosynthetic process; fatty acid metabolic process; lipoxygenase pathway; hepoxilin biosynthetic process; positive regulation of gene expression; protein lipidation; positive regulation of mucus secretion; sphingolipid metabolic process; positive regulation of MAPK cascade; arachidonic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	242
	11686
	ENSG00000179477
	ENSMUSG00000032807
	O75342
	O70582
	NM_001139
	NM_009659
	NP_001130
	NP_033789
	Wikidata
View/Edit Human	View/Edit Mouse

Arachidonate 12-lipoxygenase, 12R type, also known as ALOX12B, 12R-LOX, and arachidonate lipoxygenase 3, is a lipoxygenase-type enzyme composed of 701 amino acids and encoded by the ALOX12B gene. The gene is located on chromosome 17 at position 13.1 where it forms a cluster with two other lipoxygenases, ALOXE3 and ALOX15B. Among the human lipoxygenases, ALOX12B is most closely (54% identity) related in amino acid sequence to ALOXE3