ALPK1

ALPK1
Identifiers
Aliases	ALPK1, 8430410J10Rik, LAK, alpha kinase 1, ROSAH
External IDs	OMIM: 607347; MGI: 1918731; HomoloGene: 11849; GeneCards: ALPK1; OMA:ALPK1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	112,442,621 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	127,574,176 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; tendon of biceps brachii; ; blood; ; pancreatic ductal cell; ; monocyte; ; Achilles tendon; ; gastric mucosa; ; spleen; ; sural nerve; ; skin of abdomen;
	Top expressed in
	granulocyte; ; ventricular zone; ; spermatid; ; esophagus; ; embryo; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; ATP binding; kinase activity; protein serine/threonine kinase activity; protein binding; monosaccharide binding;
Cellular component	cytoplasm; cytosol;
Biological process	protein phosphorylation; phosphorylation; immune system process; cytoplasmic pattern recognition receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	80216
	71481
	ENSG00000073331
	ENSMUSG00000028028
	Q96QP1
	Q9CXB8
	NM_001102406; NM_001253884; NM_025144
	NM_027808
	NP_001095876; NP_001240813; NP_079420
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-protein kinase 1 is an enzyme that in humans is encoded by the ALPK1 gene.

Unlike most eukaryotic kinases, alpha kinases, such as LAK, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.[supplied by OMIM]